Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene

@article{Huff2011WilmsTA,
  title={Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene},
  author={Vicki Huff},
  journal={Nature Reviews Cancer},
  year={2011},
  volume={11},
  pages={111-121}
}
Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on… CONTINUE READING
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