• Biology, Medicine
  • Published in
    Journal of the American…
    2000

Wilms' tumor suppressor gene WT1: from structure to renal pathophysiologic features.

@article{Mrowka2000WilmsTS,
  title={Wilms' tumor suppressor gene WT1: from structure to renal pathophysiologic features.},
  author={Christian Mrowka and Andreas Schedl},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2000},
  volume={11 Suppl 16},
  pages={
          S106-15
        }
}
Normal development of the kidney is a highly complex process that requires precise orchestration of proliferation, differentiation, and apoptosis. In the past few years, a number of genes that regulate these processes, and hence play pivotal roles in kidney development, have been identified. The Wilms' tumor suppressor gene WT1 has been shown to be one of these essential regulators of kidney development, and mutations in this gene result in the formation of tumors and developmental… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Regulation of vascular endothelial growth factor, VEGF, gene promoter by the tumor suppressor, WT1.

  • Frontiers in bioscience : a journal and virtual library
  • 2007
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

WT1 Gene Mutation, p.R462W, in a 46,XY DSD Patient from Egypt with Gonadoblastoma and Review of the Literature.

  • Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

Functional Role of WT 1 in Prostate Cancer

Gail C. Fraizer, Kurtis Eisermann, +5 authors Steven J. Kuerbitz
  • 2016
VIEW 2 EXCERPTS
CITES BACKGROUND