Wilms' tumor gene 1 transcript levels in leukapheresis of peripheral blood hematopoietic cells predict relapse risk in patients autografted for acute myeloid leukemia.

@article{Messina2014WilmsTG,
  title={Wilms' tumor gene 1 transcript levels in leukapheresis of peripheral blood hematopoietic cells predict relapse risk in patients autografted for acute myeloid leukemia.},
  author={Carlo Messina and Anna Candoni and Matteo G. Carrabba and Cristina Tresoldi and Elisa Sala and Michela Tassara and Alessandra Crippa and Jacopo Peccatori and Andrea P. Assanelli and Salvatore Gattillo and Laura Bellio and Renato Fanin and Fabio Ciceri and Massimo Bernardi},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2014},
  volume={20 10},
  pages={1586-91}
}
Autologous hematopoietic stem cell transplantation (ASCT) is a curative option alternative to allogeneic transplantation for patients with acute myeloid leukemia (AML). Relapse after ASCT can be due to contamination with leukemic blasts of autologous peripheral blood stem cells (PBSCs) collected by leukapheresis (LK). Identification and quantification of a minimal residual disease (MRD) marker in PBSCs could be relevant in determining the relapse risk after ASCT. High levels of the WT1 gene… CONTINUE READING

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