Wilms' tumor 1 splice variants have opposite effects on the tumorigenicity of adenovirus-transformed baby-rat kidney cells.

@article{Menke1996WilmsT1,
  title={Wilms' tumor 1 splice variants have opposite effects on the tumorigenicity of adenovirus-transformed baby-rat kidney cells.},
  author={Aswin L. Menke and Nicole Riteco and Roeland C H J van Ham and C K. De Bruyne and F. Rauscher and Alex J van der Eb and Aart G. Jochemsen},
  journal={Oncogene},
  year={1996},
  volume={12 3},
  pages={537-46}
}
The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the four zinc-fingers and of three residues (K-T-S) between zinc… CONTINUE READING