Will xenon be a stranger or a friend?: the cost, benefit, and future of xenon anesthesia.

@article{Goto2003WillXB,
  title={Will xenon be a stranger or a friend?: the cost, benefit, and future of xenon anesthesia.},
  author={T. Goto and Y. Nakata and S. Morita},
  journal={Anesthesiology},
  year={2003},
  volume={98 1},
  pages={
          1-2
        }
}
Xenon is both an old and a new anesthetic. Although its anesthetic properties have been known for more than 50 yr, it was largely forgotten until 1990, mainly because of its high cost. Aside from this problem, xenon possesses many of the characteristics of an ideal anesthetic. For example, its blood–gas partition coefficient is extremely small (0.115), yielding rapid emergence from anesthesia regardless of the duration of anesthesia. It lacks teratogenicity, and it produces analgesia, thereby… Expand
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Halothane and isoflurane exhibited considerable inhibitory effects on voltage-gated cardiac Ca2+ and K+ currents important for the duration of action potentials and the repolarization. Expand
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Unlike hydrocarbon-based gaseous anesthetics, Xe does not significantly alter any measured electrical, mechanical, or metabolic factors, or the nitric oxide–dependent flow response in isolated hearts, at least partly because Xedoes not alter the major cation currents as shown here for cardiac myocytes. Expand
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This first randomized controlled multicenter trial on the use of xenon as an inhalational anesthetic confirms that xenon in oxygen provides effective and safe anesthesia, with the advantage of a more rapid recovery when compared with anesthesia using isoflurane–nitrous oxide. Expand
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The MAC-awake of xenon is 33% or 0.46 times its MAC, a traditional index of hypnotic potency of an inhalational anesthetic that is smaller than that for N2O but greater than those for isoflurane and sevoflureane. Expand
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Examination of haemodynamic response and catecholamine release during anaesthesia with xenon found that xenon anaesthesia was associated with a high degree of cardiovascular stability and adrenaline concentrations were reduced significantly in all groups. Expand
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