Will tuberculosis become resistant to all antibiotics?

  title={Will tuberculosis become resistant to all antibiotics?},
  author={Christopher Dye and Marcos Antonio Espinal},
  journal={Proceedings. Biological sciences},
  volume={268 1462},
The discovery of high prevalences of antibiotic resistance in some pathogens, in some parts of the world, has provoked fears of a widespread loss of drug efficacy. Here, we use a mathematical model to investigate the evolution of resistance to four major anti-tuberculosis drugs (isoniazid, rifampicin, ethambutol and streptomycin) in 47 sites around the world. The model provides a new method of estimating the relative risk of treatment failure for patients carrying drug-resistant strains and the… CONTINUE READING


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