Will the Making of Plasmacytoid Dendritic Cells in Vitro Help Unravel Their Mysteries?

@article{Banchereau2000WillTM,
  title={Will the Making of Plasmacytoid Dendritic Cells in Vitro Help Unravel Their Mysteries?},
  author={Jacques Banchereau and Bali Pulendran and Ralph Marvin Steinman and Karolina Anna Palucka},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={f39 - f44}
}
In this issue, two papers describe the in vitro generation of an intriguing subset of human dendritic cells (DCs), the plasmacytoid DCs (pDCs [1, 2]). For nearly 20 years after their discovery (3), DCs had to be painstakingly isolated from tissues (4). Progress was rather slow, as DCs represent a minor cell population in all tissues, and relatively few investigators appreciated their importance in antigen presentation and the control of immunity. In 1992, in vitro culture systems were… CONTINUE READING
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