Will chronic intracerebroventricular saralasin infusion produce selective blockade of brain angiotensin II receptors in the rat?

@article{Bruner1983WillCI,
  title={Will chronic intracerebroventricular saralasin infusion produce selective blockade of brain angiotensin II receptors in the rat?},
  author={C. A. Bruner and Joel M Weaver and Gregory D. Fink},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1983},
  volume={226 1},
  pages={13-8}
}
In an attempt to produce chronic, selective, pharmacological blockade of brain angiotensin II (AII) receptors, we infused saralasin (1sar, 8ala-angiotensin II), a competitive AII receptor antagonist, into the cerebral ventricles of rats for 5 days. We found that i.c.v. saralasin infusion at a dose of 12 micrograms/hr selectively blocked brain AII receptors… CONTINUE READING