Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?

@article{Karagiannis2007WillBH,
  title={Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?},
  author={Tom C. Karagiannis and Assam El-Osta},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={61-65}
}
Histone deacetylase (HDAC) inhibitors can induce differentiation, cell cycle and growth arrest or in certain cases apoptosis in cancer cells. In a remarkably short period of time, especially considering that their mechanism of action remains largely undefined, HDAC inhibitors have realized both success and failure as therapeutics for cancer in clinical… CONTINUE READING