Wild-type p53-dependent etoposide-induced apoptosis mediated by caspase-3 activation in human glioma cells.

@article{Yin2000WildtypePE,
  title={Wild-type p53-dependent etoposide-induced apoptosis mediated by caspase-3 activation in human glioma cells.},
  author={Dong Yin and Norihiko Tamaki and Takashi Kokunai},
  journal={Journal of neurosurgery},
  year={2000},
  volume={93 2},
  pages={289-97}
}
OBJECT In an attempt to understand the roles of several apoptosis-related genes in human glioma cells, the authors investigated the relationship of wild-type p53, interleukin-1beta-converting enzyme (ICE), caspase-3 (CPP32), bax, and bcl-2 to the apoptotic response of three glioma cell lines after treatment with etoposide. METHODS A human glioma cell line (U-87MG) that expresses wild-type p53, one that expresses mutant p53 (T-98G), and a T-98G derivative (T-98G/p53) that was transfected with… CONTINUE READING