Wild-type p53 controls cell motility and invasion by dual regulation of MET expression.

  title={Wild-type p53 controls cell motility and invasion by dual regulation of MET expression.},
  author={Chang-Il Hwang and Andres Matoso and David C. Corney and Andrea Flesken-Nikitin and Stefanie K{\"o}rner and Wei Wang and Carla Boccaccio and Snorri Thorgeirsson and Paolo Maria Comoglio and Heiko Hermeking and Alexander Yu Nikitin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 34},
Recent observations suggest that p53 mutations are responsible not only for growth of primary tumors but also for their dissemination. However, mechanisms involved in p53-mediated control of cell motility and invasion remain poorly understood. By using the primary ovarian surface epithelium cell culture, we show that conditional inactivation of p53 or expression of its mutant forms results in overexpression of MET receptor tyrosine kinase, a crucial regulator of invasive growth. At the same… CONTINUE READING
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Regulation of the c-met proto-oncogene promoter by p53

  • DW Seol, ChenQ, SmithML, R Zarnegar
  • J Biol Chem
  • 1999
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