Wild-type p53 can down-modulate the activity of various promoters.

@article{Ginsberg1991WildtypePC,
  title={Wild-type p53 can down-modulate the activity of various promoters.},
  author={Dorit Ginsberg and Fatima Mechta and M. Yaniv and Moshe Oren},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 22},
  pages={
          9979-83
        }
}
The wild-type (wt) p53 protein is the product of a tumor suppressor gene that is a frequent target for inactivation in many types of tumors. The nuclear localization of the protein, as well as additional features, suggest that it may be involved in the regulation of gene expression. To explore this possibility, the effects of overproduced wt p53 were investigated in a number of systems. Induction of growth arrest via the antiproliferative effect of wt p53 greatly impaired the ability of cells… CONTINUE READING
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A comparison of the biological activities of wild-type and mutant p53.

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