Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

@article{Mukhopadhyay1995WildtypePA,
  title={Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.},
  author={Debabrata Mukhopadhyay and Leonidas Tsiokas and Vikas P. Sukhatme},
  journal={Cancer research},
  year={1995},
  volume={55 24},
  pages={
          6161-5
        }
}
Angiogenesis, the development of new capillaries, is tightly controlled by the balance of positive and negative regulatory pathways. A newly described angiogenic factor, vascular endothelial growth factor/vascular permeability factor (VEGF/VPF), binds exclusively to endothelial cells and promotes their proliferation. Here we have studied the role of p53, a tumor suppressor, and v-Src, an oncogene on VEGF regulation. Wild-type p53 down-regulated endogenous VEGF mRNA level, as well as VEGF… CONTINUE READING

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