Wild-type p53 and p73 negatively regulate expression of proliferation related genes

@article{Scian2008WildtypePA,
  title={Wild-type p53 and p73 negatively regulate expression of proliferation related genes},
  author={Mariano J. Scian and Evie H. Carchman and Lathika Mohanraj and Katherine E Roth Stagliano and Michelle A. E. Anderson and Debabrita Deb and Brittany M Crane and Touru Kiyono and Brad Windle and Swati Palit Deb},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={2583-2593}
}
When normal cells come under stress, the wild-type (WT) p53 level increases resulting in the regulation of gene expression responsible for growth arrest or apoptosis. Here we show that elevated levels of WT p53 or its homologue, p73, inhibit expression of a number of cell cycle regulatory and growth promoting genes. Our analysis also identified a group of genes whose expression is differentially regulated by WT p53 and p73. We have infected p53-null H1299 human lung carcinoma cells with… CONTINUE READING

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