Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

@article{Halazonetis1993WildtypePA,
  title={Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.},
  author={Thanos D Halazonetis and L. Berkley Davis and A. T. Kandil},
  journal={The EMBO journal},
  year={1993},
  volume={12 3},
  pages={
          1021-8
        }
}
p53 is a negative regulator of cell growth. The majority of human tumors express mutant p53 proteins, which can be distinguished from wild-type by their immuno-reactivity to a panel of conformation-specific monoclonal antibodies, such as PAb421, PAb1620 and PAb246. Wild-type p53 has sequence-specific DNA binding activity. We demonstrate that upon binding DNA wild-type p53 changes conformation at both its N- and C-termini, such that it adopts a 'mutant'-like conformation. Very few of the known… CONTINUE READING
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