Wild type microglia arrest pathology in a mouse model of Rett syndrome

@inproceedings{Derecki2012WildTM,
  title={Wild type microglia arrest pathology in a mouse model of Rett syndrome},
  author={No{\"e}l C. Derecki and James C. Cronk and Zhenjie Lu and Eric H. Xu and Stephen B G Abbott and Patrice G Guyenet and Jonathan Kipnis},
  booktitle={Nature},
  year={2012}
}
Rett syndrome is an X-linked autism spectrum disorder. The disease is characterized in most cases by mutation of the MECP2 gene, which encodes a methyl-CpG-binding protein. Although MECP2 is expressed in many tissues, the disease is generally attributed to a primary neuronal dysfunction. However, as shown recently, glia, specifically astrocytes, also contribute to Rett pathophysiology. Here we examine the role of another form of glia, microglia, in a murine model of Rett syndrome… CONTINUE READING
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