Wild-type human SOD1 overexpression does not accelerate motor neuron disease in mice expressing murine Sod1<ce:sup loc=post>G86R</ce:sup>

@article{Audet2010WildtypeHS,
  title={Wild-type human SOD1 overexpression does not accelerate motor neuron disease in mice expressing murine Sod1<ce:sup loc=post>G86R</ce:sup>},
  author={Jean-Nicolas Audet and Genevieve Gowing and Jean-Pierre Julien},
  journal={Neurobiology of Disease},
  year={2010},
  volume={40},
  pages={245-250}
}
Approximately 10% of the cases of amyotrophic lateral sclerosis (ALS) are inherited, with the majority of identified linkages in the gene encoding Cu/Zn superoxide dismutase (SOD1). Recent studies showed that human wild-type SOD1 (SOD1(WT)) overexpression accelerated disease in mice expressing human SOD1 mutants linked to ALS. However, there is a controversy whether the exacerbation mechanism occurs through coaggregation of human SOD1(WT) with SOD1 mutants, stabilization by SOD1(WT) of toxic… CONTINUE READING

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