Wild-type but not mutant APC associates with the microtubule cytoskeleton.

@article{Smith1994WildtypeBN,
  title={Wild-type but not mutant APC associates with the microtubule cytoskeleton.},
  author={Kayla J. Smith and Daniel B. Levy and Pamela Maupin and Thomas D. Pollard and Bert Vogelstein and Ken W Kinzler},
  journal={Cancer research},
  year={1994},
  volume={54 14},
  pages={3672-5}
}
The adenomatous polyposis coli protein (APC) is mutated in familial adenomatous polyposis patients as well as in sporadic colorectal tumors. In an attempt to further understand the function of APC, the subcellular localization of APC was examined. Wild-type and mutant forms of APC were expressed in mammalian cells and protein detected by immunofluorescence using monoclonal and polyclonal antibodies. Staining of wildtype APC protein revealed a filamentous network which extended throughout the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 114 extracted citations

BIM1 encodes a microtubule-binding protein in yeast.

Molecular biology of the cell • 1997
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Association between wild - type and mutant All ' gene products

K. A. Johnson, K. i. Smith, P. IL. Hill, B.. Vogelatein, K. W. Kinsler
Cancer Res . • 1993

Association of the APC gene product with beta catenin

B. Rubinfeld, B. Sousa, +4 authors P. Polakis
Science ( Washington DC ) • 1993

Association of the APC tumor suppres sorprotein with calenins

1.-K. Su, B. Vogetetein, K. W. Klnzler
Science ( Washington DC ) • 1993

The APC gene product in normal and tumor cells.

Proceedings of the National Academy of Sciences of the United States of America • 1993

Similar Papers

Loading similar papers…