Wild-type but not mutant APC associates with the microtubule cytoskeleton.

  title={Wild-type but not mutant APC associates with the microtubule cytoskeleton.},
  author={Kayla J. Smith and Daniel B. Levy and Pamela Maupin and Thomas D. Pollard and Bert Vogelstein and Ken W Kinzler},
  journal={Cancer research},
  volume={54 14},
The adenomatous polyposis coli protein (APC) is mutated in familial adenomatous polyposis patients as well as in sporadic colorectal tumors. In an attempt to further understand the function of APC, the subcellular localization of APC was examined. Wild-type and mutant forms of APC were expressed in mammalian cells and protein detected by immunofluorescence using monoclonal and polyclonal antibodies. Staining of wildtype APC protein revealed a filamentous network which extended throughout the… CONTINUE READING

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