Wild type but not deltaF508 CFTR inhibits Na+ conductance when coexpressed in Xenopus oocytes.

@article{Mall1996WildTB,
  title={Wild type but not deltaF508 CFTR inhibits Na+ conductance when coexpressed in Xenopus oocytes.},
  author={Marcus Mall and Annette Hipper and Rainer Greger and Karl Kunzelmann},
  journal={FEBS letters},
  year={1996},
  volume={381 1-2},
  pages={47-52}
}
Airway epithelial cells bearing mutations of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) possess an increased Na+ conductance along with their well described defect of cAMP dependent Cl- conductance. Currently it is not clear, how this occurs, and whether it is due to a CFTR control of epithelial Na+ conductances which might be defective in CF patients. In the present study, we have tried to identify possible interactions between both CFTR and the epithelial Na… CONTINUE READING

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