Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.

@article{Miller2007WildtypeAM,
  title={Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.},
  author={Renee M. Miller and Gretchen L. Kiser and Tamma Kaysser-Kranich and Cindy Casaceli and Emanuela Colla and Michael K.S. Lee and Chockalingham Palaniappan and Howard J. Federoff},
  journal={Experimental neurology},
  year={2007},
  volume={204 1},
  pages={421-32}
}
The pathophysiological processes that cause Parkinson's disease (PD) affect dopamine neurons residing in the substantia nigra with devastating consequences for normal movement. One important gene involved in both familial and sporadic PD is alpha-synuclein. We have generated three strains of alpha-synuclein transgenic mice to study the pathologic consequences of the targeted expression of mutant or wild-type human alpha-synuclein in a model system. We have analyzed gene expression patterns in… CONTINUE READING