Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus.

@article{Coleman2014WildtypeAI,
  title={Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus.},
  author={Christopher M. Coleman and Krystal L Matthews and Lindsay Goicochea and Matthew B. Frieman},
  journal={The Journal of general virology},
  year={2014},
  volume={95 Pt 2},
  pages={408-12}
}
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging highly pathogenic virus causing almost 50 % lethality in infected individuals. The development of a small-animal model is critical for the understanding of this virus and to aid in development of countermeasures against MERS-CoV. We found that BALB/c, 129/SvEv and 129/SvEv STAT1 knockout mice are not permissive to MERS-CoV infection. The lack of infection may be due to the low level of mRNA and protein for the MERS… CONTINUE READING
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