Wild type and K897T polymorphisms of the hERG gene: modeling the APD in Caucasians

@inproceedings{Glinka2012WildTA,
  title={Wild type and K897T polymorphisms of the hERG gene: modeling the APD in Caucasians},
  author={Anna Glinka and Sebastian Polak},
  booktitle={Bioinformation},
  year={2012}
}
The presented study aims to assess the possibility of simulating changes in cardiac cell electrophysiology due to K897T polymorphism in the Caucasian population. In the first part of the experiment, the parameters of the equations describing channel gating were fitted to the experimental data. Then, the action potentials of midmyocardial cells of 100 individuals were simulated in the in vitro - in vivo extrapolation system - ToxComp. Mean APD90 for the entire simulated population is 352.05 ms… CONTINUE READING
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  • Br J Pharmacol
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