Wild-type adenoviruses from groups A–F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent

@article{Appledorn2008WildtypeAF,
  title={Wild-type adenoviruses from groups A–F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent},
  author={Daniel M. Appledorn and Anne Kiang and Aaron F. McBride and Haixiang Jiang and Sergey S Seregin and Jeannine M Scott and Rowan Stringer and Youssef A Kousa and Mary Beth Hoban and Mike Frank and Andrea Amalfitano},
  journal={Gene Therapy},
  year={2008},
  volume={15},
  pages={885-901}
}
Alternative human and non-human Ad serotype vectors are currently studied for gene therapy and/or vaccine applications to capitalize upon their likely ability to avoid pre-existing immunity to HAd5. However, relatively little attention has been given to the nature and scope of innate immune responses generated by alternative Ad serotypes. In this study, we characterized several innate immune responses after intravenous administration of wild-type Ad serotypes HAd31, HAd3, HAd5, HAd37, SAd23 and… CONTINUE READING
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Adenovirus vector induced immune responses are dependent on multifaceted interactions with proteins of the alternative and classical complement pathways in vivo

  • JM Scott, A Kiang, DM Appledorn, AJ McBride, A. Amalfitano
  • Abstr 10th Annual Meeting Amer Soc of Gene Ther,
  • 2007

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