Wild-type VHL Clear Cell Renal Cell Carcinomas Are a Distinct Clinical and Histologic Entity: A 10-Year Follow-up.

@article{Dagher2016WildtypeVC,
  title={Wild-type VHL Clear Cell Renal Cell Carcinomas Are a Distinct Clinical and Histologic Entity: A 10-Year Follow-up.},
  author={Julien Dagher and Sol{\`e}ne-Florence Kammerer-Jacquet and Ang{\'e}lique Brunot and Ad{\'e}la{\"i}de Pladys and Jean-Jacques Patard and Karim Bensalah and Christophe Perrin and Gr{\'e}gory Verhoest and Jean Mosser and Alexandra Lespagnol and C{\'e}cile Vigneau and Fr{\'e}d{\'e}ric Dugay and Marc-Antoine Belaud-Rotureau and Nathalie Rioux-Leclercq},
  journal={European urology focus},
  year={2016},
  volume={1 3},
  pages={
          284-290
        }
}
BACKGROUND Clear cell renal cell carcinoma (ccRCC) is an aggressive tumor with 50% risk of metastases at initial diagnosis or at follow-up. An inactivation of the tumor-suppressor gene von Hippel-Lindau (VHL) is present in >70% of sporadic cases by two of three different mechanisms: locus deletion, gene mutation, or promoter hypermethylation. OBJECTIVE To correlate the complete status of the VHL gene with clinical and pathologic criteria. DESIGN, SETTING, AND PARTICIPANTS We retrospectively… CONTINUE READING
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