Wild-type Puumala hantavirus infection induces cytokines, C-reactive protein, creatinine, and nitric oxide in cynomolgus macaques.

@article{Klingstrm2002WildtypePH,
  title={Wild-type Puumala hantavirus infection induces cytokines, C-reactive protein, creatinine, and nitric oxide in cynomolgus macaques.},
  author={Jonas Klingstr{\"o}m and Alexander Plyusnin and Antti Vaheri and {\AA}ke Lundkvist},
  journal={Journal of virology},
  year={2002},
  volume={76 1},
  pages={444-9}
}
Hantaviruses cause two severe human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Approximately 200,000 cases are reported annually, and there is to date no specific treatment available. A major obstacle in studying the medical aspects of HFRS and HPS has been the lack of an adequate animal model. Here we show that infection of cynomolgus macaques by wild-type Puumala hantavirus resulted in typical signs of HFRS including lethargy, anorexia… CONTINUE READING

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