Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes

Abstract

This work provides functional data showing that the bacterial CYP102A1 recognises compounds metabolised by human CYP3A4, CYP2E1 and CYP1A2 and is able to catalyse different reactions. Wild-type cytochrome CYP102A1 from Bacillus megaterium is a catalytically self-sufficient enzyme, containing an NADPH-dependent reductase and a P450 haem domain fused in a… (More)
DOI: 10.1007/s00775-006-0188-4

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