Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc.

@article{Roy2008WildtypeAR,
  title={Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc.},
  author={Upal Kunal Basu Roy and Rebecca S Henkhaus and Natalia A. Ignatenko and Jessica Mora and Kimberly E Fultz and Eugene W. Gerner},
  journal={Molecular carcinogenesis},
  year={2008},
  volume={47 12},
  pages={947-55}
}
Genetic evidence suggests that caveolin-1, an essential component of membrane caveolae, acts as a tumor promoter in some, and a tumor suppressor in other cancers. The role of caveolin-1 in colon carcinogenesis is controversial. We report here, for the first time, that caveolin-1 is transcriptionally induced in colon cancer cells in response to conditional… CONTINUE READING