Wild-Type Measles Virus is Intrinsically Dual-Tropic

  title={Wild-Type Measles Virus is Intrinsically Dual-Tropic},
  author={Makoto Takeda and Maino Tahara and Noriyo Nagata and Fumio Seki},
  booktitle={Front. Microbio.},
Measles is a highly contagious disease that causes temporary and severe immunosuppression in patients. Signaling lymphocyte activation molecule (SLAM) expressed on cells of the immune system functions as a receptor for measles virus (MV). In addition to SLAM, vaccine strains of MV also use a ubiquitously expressed complement regulatory protein, CD46, as a receptor, whereas wild-type (wt) MV strains do not use this receptor. However, recent studies have indicated that SLAM is not the sole… CONTINUE READING
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