Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis.

@article{SurmannSchmitt2009Wif1IE,
  title={Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis.},
  author={Cordula Surmann-Schmitt and Nathalie Widmann and Uwe Dietz and Bernhard Saeger and Nicole Eitzinger and Yukio Nakamura and Marianne Rattel and Richard Latham and Christine Hartmann and Helga von der Mark and Georg Schett and Klaus von der Mark and Michael Stock},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 20},
  pages={3627-37}
}
Wnt factors are involved in the regulation of all steps of cartilage development. The activity of Wnt factors is generally regulated at the extracellular level by factors like the Dkk family, sFRPs, Cerberus and Wnt inhibitory factor 1 (Wif-1). Here we report that Wif-1 is highly expressed at cartilage-mesenchyme interfaces of the early developing skeleton. In fetal and postnatal skeletal development, Wif-1 is expressed in a sharply restricted zone in the upper hyaline layer of epiphyseal and… CONTINUE READING

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