Widespread tissue distribution of human chymase.

  title={Widespread tissue distribution of human chymase.},
  author={Hidenori Urata and Frank W. Strobel and Detlev Ganten},
  journal={Journal of hypertension. Supplement : official journal of the International Society of Hypertension},
  volume={12 9},
OBJECTIVE Human chymase is a potent and specific angiotensin (Ang) II-forming serine proteinase. Although the histological localization of heart chymase indicated that this enzyme contributes to extracellular Ang II formation, the systemic distribution and the level of expression of chymase in various human tissues have not been clarified. This information is needed to elucidate the human tissue Ang II system. METHODS Levels of immunoreactivity and enzymatic activity in various human tissues… CONTINUE READING


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