Widespread structural brain changes in OCD: A systematic review of voxel-based morphometry studies

@article{Piras2015WidespreadSB,
  title={Widespread structural brain changes in OCD: A systematic review of voxel-based morphometry studies},
  author={Federica Piras and Fabrizio Piras and Chiara Chiapponi and Paolo Girardi and Carlo Caltagirone and Gianfranco Spalletta},
  journal={Cortex},
  year={2015},
  volume={62},
  pages={89-108}
}
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154 Citations

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Alterations of gray and white matter morphology in obsessive compulsive disorder.
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Structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls are tested using voxel-based morphometry (VBM), finding alterations may be associated with prominent OCD symptoms.
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TLDR
The results suggest that gray matter abnormalities in the PFC may indicate homogeneity between the two diseases, and in children and adolescents, structural alterations in schizophrenia mainly involve the fronto-temporal and cortico-insula circuits, whereas those in OCD mainly involveThe prefrontal-parietal and the prefrontal-striatal circuits.
Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder
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Novel evidence of widespread microstructural alterations in OCD is provided and it is suggested that OCD may involve abnormalities affecting a broader network of regions than commonly believed.
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