Widespread structural brain changes in OCD: A systematic review of voxel-based morphometry studies

@article{Piras2015WidespreadSB,
  title={Widespread structural brain changes in OCD: A systematic review of voxel-based morphometry studies},
  author={Federica Piras and F. Piras and C. Chiapponi and P. Girardi and G. Spalletta},
  journal={Cortex},
  year={2015},
  volume={62},
  pages={89-108}
}
The most widely accepted model of obsessive-compulsive disorder (OCD) assumes brain abnormalities in the "affective circuit", mainly consisting of volume reduction in the medial orbitofrontal, anterior cingulate and temporolimbic cortices, and tissue expansion in the striatum and thalamus. The advent of whole-brain, voxel-based morphometry (VBM) has provided increasing evidence that regions outside the "affective" orbitofronto-striatal circuit are involved in OCD. Nevertheless, potential… Expand
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