Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution.

@article{Ewing2015WidespreadSL,
  title={Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution.},
  author={Adam D. Ewing and Anthony Gacita and Laura D Wood and Florence F T Ma and DongMei Xing and Min-Sik Kim and Srikanth Srinivas Manda and Gabriela Abril and Gavin C. Pereira and Alvin P. Makohon-Moore and Leendert H J Looijenga and Ad J. M. Gillis and Ralph H. Hruban and Robert Albert Anders and Katharine E. Romans and Akhilesh Pandey and Christine A Iacobuzio-Donahue and Bert Vogelstein and Kenneth W. Kinzler and Haig H. Kazazian and Szilvia Solyom},
  journal={Genome research},
  year={2015},
  volume={25 10},
  pages={1536-45}
}
Somatic L1 retrotransposition events have been shown to occur in epithelial cancers. Here, we attempted to determine how early somatic L1 insertions occurred during the development of gastrointestinal (GI) cancers. Using L1-targeted resequencing (L1-seq), we studied different stages of four colorectal cancers arising from colonic polyps, seven pancreatic carcinomas, as well as seven gastric cancers. Surprisingly, we found somatic L1 insertions not only in all cancer types and metastases but… CONTINUE READING
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