Widespread skin-limited adult Langerhans cell histiocytosis: long-term follow-up with good response to interferon alpha.

@article{Chang2002WidespreadSA,
  title={Widespread skin-limited adult Langerhans cell histiocytosis: long-term follow-up with good response to interferon alpha.},
  author={Sung Eun Chang and G J Koh and Jee Choi and Kwang Hoon Lee and K. J. Sung and Kee Chan Moon and Jai Kyoung Koh},
  journal={Clinical and experimental dermatology},
  year={2002},
  volume={27 2},
  pages={135-7}
}
Langerhans cell histiocytosis (LCH) most frequently involves bone, but also involves the skin in 40% of cases; in 10% of patients it is limited to the skin. Cutaneous findings of skin-limited LCH are scaly papules, vesicles, nodules, tumours with erosion, ulceration, or crusting and/or purpura. We report a case of widespread adult-onset LCH confined to skin in which topical carmustine, photochemotherapy, systemic steroids, and 2-chlorodeoxyadenosine were only partially effective. However… CONTINUE READING