Widespread seasonal gene expression reveals annual differences in human immunity and physiology

@inproceedings{Dopico2015WidespreadSG,
  title={Widespread seasonal gene expression reveals annual differences in human immunity and physiology},
  author={Xaquin Castro Dopico and Marina Evangelou and Ricardo C Ferreira and Hui Guo and Marcin L. Pekalski and Deborah J. Smyth and Nicholas Cooper and Oliver S. Burren and Anthony J. C. Fulford and Branwen J. Hennig and Andrew M Prentice and Anette-G. Ziegler and Ezio Bonifacio and Chris Wallace and John A. Todd},
  booktitle={Nature communications},
  year={2015}
}
Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and… CONTINUE READING

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