Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation.

  title={Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation.},
  author={Rammohan Narayanaswamy and Matthew Levy and Mark Tsechansky and Gwendolyn M. Stovall and Jeremy D O'Connell and Jennifer A. Mirrielees and Andrew D. Ellington and Edward M. Marcotte},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 25},
Proteins are likely to organize into complexes that assemble and disassemble depending on cellular needs. When approximately 800 yeast strains expressing GFP-tagged proteins were grown to stationary phase, a surprising number of proteins involved in intermediary metabolism and stress response were observed to form punctate cytoplasmic foci. The formation of these discrete physical structures was confirmed by immunofluorescence and mass spectrometry of untagged proteins. The purine biosynthetic… CONTINUE READING
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