Widespread recombination within human parechoviruses: analysis of temporal dynamics and constraints.

@article{Benschop2008WidespreadRW,
  title={Widespread recombination within human parechoviruses: analysis of temporal dynamics and constraints.},
  author={Kimberley S M Benschop and Ciğdem H Williams and Katja C. Wolthers and Glyn Stanway and Peter Simmonds},
  journal={The Journal of general virology},
  year={2008},
  volume={89 Pt 4},
  pages={1030-5}
}
Human parechoviruses (HPeVs), members of the family Picornaviridae, are classified into six types. To investigate the dynamics and likelihood of recombination among HPeVs, we compared phylogenies of two distant regions (VP1 and 3Dpol) of 37 HPeV isolates (types 1 and 3-5) and prototype sequences (types 1-6). Evidence for frequent recombination between HPeV1, 4, 5 and 6 was found. The likelihood of recombination was correlated with the degree of VP1 divergence and differences in isolation dates… CONTINUE READING
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