Widespread origin of the primate mesofrontal dopamine system.

  title={Widespread origin of the primate mesofrontal dopamine system.},
  author={Solomon Williams and Patricia S. Goldman-Rakic},
  journal={Cerebral cortex},
  volume={8 4},
The dopaminergic innervation of the frontal cortex, commonly implicated in psychiatric and neurological disorders, has traditionally been associated with a circumscribed midline group of ventral tegmental area (VTA) neurons. We have employed a combination of retrograde tracing, using fluorescent dyes, and tyrosine hydroxylase (TH) immunohistochemistry to amplify knowledge of frontal cortex-projecting dopamine (DA) neurons in non-human primates. Injections of retrograde fluorochromes were made… CONTINUE READING
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