Widespread optogenetic expression in macaque cortex obtained with MR-guided, convection enhanced delivery (CED) of AAV vector to the thalamus

@article{YazdanShahmorad2018WidespreadOE,
  title={Widespread optogenetic expression in macaque cortex obtained with MR-guided, convection enhanced delivery (CED) of AAV vector to the thalamus},
  author={Azadeh Yazdan-Shahmorad and Nan Tian and Viktor Kharazia and Lluis Samaranch and Adrian P. Kells and John R. Bringas and Jiwei He and Krystof S. Bankiewicz and Philip N. Sabes},
  journal={Journal of Neuroscience Methods},
  year={2018},
  volume={293},
  pages={347-358}
}
BACKGROUND In non-human primate (NHP) optogenetics, infecting large cortical areas with viral vectors is often a difficult and time-consuming task. Previous work has shown that parenchymal delivery of adeno-associated virus (AAV) in the thalamus by convection-enhanced delivery (CED) can lead to large-scale transduction via axonal transport in distal areas including cortex. We used this approach to obtain widespread cortical expression of light-sensitive ion channels. NEW METHOD AAV vectors co… CONTINUE READING
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