Widespread occurrence of alpha-synuclein/NACP-immunoreactive neuronal inclusions in juvenile and adult-onset Hallervorden-Spatz disease with Lewy bodies.

@article{Wakabayashi1999WidespreadOO,
  title={Widespread occurrence of alpha-synuclein/NACP-immunoreactive neuronal inclusions in juvenile and adult-onset Hallervorden-Spatz disease with Lewy bodies.},
  author={Keiji Wakabayashi and Makoto Yoshimoto and Takao Fukushima and Reiji Koide and Yoh Horikawa and Takashi Morita and Hitoshi Takahashi},
  journal={Neuropathology and applied neurobiology},
  year={1999},
  volume={25 5},
  pages={363-8}
}
Alpha-Synuclein (originally called precursor of the non-Abeta component of Alzheimer's disease amyloid-NACP) is a presynaptic nerve terminal protein and is now known to be a major component of Lewy bodies (LBs) in Parkinson's disease. Previous studies have shown that LBs are occasionally found in patients with Hallervorden-Spatz disease (HSD), a hereditary or sporadic neuroaxonal dystrophy. Therefore, an immunocytochemical examination of the brain tissues from two patients with HSD for alpha… CONTINUE READING
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