Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids.

@article{GarcaEspinosa2007WidespreadNE,
  title={Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids.},
  author={Maria Antonia Garc{\'i}a-Espinosa and Reidar Wallin and Susan M. Hutson and A. J. Sweatt},
  journal={Journal of neurochemistry},
  year={2007},
  volume={100 6},
  pages={1458-68}
}
Transamination of the branched-chain amino acids produces glutamate and branched-chain alpha-ketoacids. The reaction is catalyzed by branched-chain aminotransferase (BCAT), of which there are cytosolic and mitochondrial isoforms (BCATc and BCATm). BCATc accounts for 70% of brain BCAT activity, and contributes at least 30% of the nitrogen required for glutamate synthesis. In previous work, we showed that BCATc is present in the processes of glutamatergic neurons and in cell bodies of GABAergic… CONTINUE READING
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