Widespread mitochondrial depletion via mitophagy does not compromise necroptosis.

Abstract

Programmed necrosis (or necroptosis) is a form of cell death triggered by the activation of receptor interacting protein kinase-3 (RIPK3). Several reports have implicated mitochondria and mitochondrial reactive oxygen species (ROS) generation as effectors of RIPK3-dependent cell death. Here, we directly test this idea by employing a method for the specific… (More)
DOI: 10.1016/j.celrep.2013.10.034

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