Widespread microRNA repression by Myc contributes to tumorigenesis

@article{Chang2008WidespreadMR,
  title={Widespread microRNA repression by Myc contributes to tumorigenesis},
  author={Tsung-Cheng Chang and Duonan Yu and Yun-Sil Lee and Erik A. Wentzel and Dan E Arking and Kristin M West and Chi V. Dang and Andrei Thomas-Tikhonenko and Joshua T Mendell},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={43-50}
}
The c-Myc oncogenic transcription factor (Myc) is pathologically activated in many human malignancies. Myc is known to directly upregulate a pro-tumorigenic group of microRNAs (miRNAs) known as the miR-17–92 cluster. Through the analysis of human and mouse models of B cell lymphoma, we show here that Myc regulates a much broader set of miRNAs than previously anticipated. Unexpectedly, the predominant consequence of activation of Myc is widespread repression of miRNA expression. Chromatin… CONTINUE READING
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