Widespread loss of gelsolin in breast cancers of humans, mice, and rats.

  title={Widespread loss of gelsolin in breast cancers of humans, mice, and rats.},
  author={Harold L. Asch and Karen Head and Ying Dong and Farah Natoli and Janet S. Winston and Jodi L Connolly and Bonnie B. Asch},
  journal={Cancer research},
  volume={56 21},
Down-regulation of gelsolin, an actin-binding protein, is frequently found in several types of transformed cells and tumors. The present study demonstrates that gelsolin protein and RNA were absent or markedly reduced in human breast cancer cell lines relative to "normal" mortal human mammary epithelial cells and benign, immortalized cell lines. Moreover, actin filaments were usually attenuated coincident with the reduction in gelsolin. Gelsolin was also missing or greatly decreased in 70% of… CONTINUE READING
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