Widespread inhibition of posttranscriptional splicing shapes the cellular transcriptome following heat shock.

Abstract

During heat shock and other proteotoxic stresses, cells regulate multiple steps in gene expression in order to globally repress protein synthesis and selectively upregulate stress response proteins. Splicing of several mRNAs is known to be inhibited during heat stress, often meditated by SRp38, but the extent and specificity of this effect have remained… (More)
DOI: 10.1016/j.celrep.2014.04.044

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@article{Shalgi2014WidespreadIO, title={Widespread inhibition of posttranscriptional splicing shapes the cellular transcriptome following heat shock.}, author={Reut Shalgi and Jessica A. Hurt and Susan Lindquist and Christopher B. Burge}, journal={Cell reports}, year={2014}, volume={7 5}, pages={1362-1370} }