Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome.

@article{Contestabile2009WidespreadIO,
  title={Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome.},
  author={Andrea Contestabile and Tatiana Fila and Alessandra Cappellini and Renata Bartesaghi and Elisabetta Ciani},
  journal={Cell proliferation},
  year={2009},
  volume={42 2},
  pages={171-81}
}
OBJECTIVES Among the many pathological aspects of Down syndrome, brain hypoplasia and mental retardation have been recently ascribed to defective proliferation of neural precursors during central nervous system development. By analogy, other features of Down syndrome, such as heart defects, gastrointestinal abnormalities, craniofacial dystrophy and reduced growth rate could be related, at least in theory, to similar proliferation impairment in peripheral tissues. MATERIALS AND METHODS In… CONTINUE READING
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