Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging

  title={Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging},
  author={Meng Liang and Yuan Zhou and Tianzi Jiang and Zhening Liu and Lixia Tian and Haihong Liu and Yihui Hao},
Using resting-state functional magnetic resonance imaging, we examined the functional connectivity throughout the entire brain in schizophrenia. The abnormalities in functional connectivity were identified by comparing the correlation coefficients of each pair of 116 brain regions between 15 patients and 15 controls. Then, the global distribution of the abnormal functional connectivities was examined. Experimental results indicated, in general, a decreased functional connectivity in… 

Whole brain resting state functional connectivity abnormalities in schizophrenia

Functional connectivity density alterations in schizophrenia

The striatal and hippocampal regions and parietal-occipital regions exhibited completely different changes in rsFCD in schizophrenia, which roughly correspond to dopamine activity in these regions in schizophrenia.

Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia

Disrupted modular organization of primary sensory brain areas in schizophrenics

A novel, resolution limit-free approach is applied to study the modular organization of resting state functional connectivity networks in a large cohort of SCZ patients, and in matched healthy controls, which provides support to the hypothesis that cognitive dysfunction in SCZ may arise from deficits occurring already at early stages of sensory processing.

Discriminative Analysis of Nonlinear Functional Connectivity in Schizophrenia

  • D. HuL. Zeng
  • Psychology
    Pattern Analysis of the Human Connectome
  • 2019
The classification results suggest that the nonlinear functional connectivity provided useful discriminative power in the diagnostic classification of schizophrenia, and the inverse changes with similar spatial distribution between thelinear and nonlinear measure may indicate the underlying compensatory mechanism between the linear and non linear functional connectivity and the complex neuronal synchronization in schizophrenia.

Brain connectivity networks in schizophrenia underlying resting state functional magnetic resonance imaging.

Overall, the resting-state findings regarding brain networks deficits have advanced the understanding of the underlying pathology of SZ, and future challenges are discussed.



Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function.

Functional MRI data show evidence of additional functional deficits in patients with negative symptoms, deficits which may explain the accompanying attentional impairment and are consistent with theoretical accounts of schizophrenia as a disorder of functional integration.

Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest

SICA showed that prefrontal and parietal areas are also functionally connected within and between hemispheres during the resting state, and showed an extremely high degree of consistency in spatial, temporal, and frequency parameters between and between subjects.

A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia

Functional connectivity in the motor cortex of resting human brain using echo‐planar mri

It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.

Interregional connectivity to primary motor cortex revealed using MRI resting state images

Using this covariance method, neural connectivity to primary motor cortex was assessed during a resting state in six healthy right‐handed volunteers and may offer in vivo noninvasive measurements of neural projections.

Functional Connectivity in Single and Multislice Echoplanar Imaging Using Resting-State Fluctuations

Correlations to left hemisphere motor cortex, visual cortex, and amygdala are measured in long resting-state scans and these correlations are extended to lower sampling rate multislice echoplanar acquisitions and other right/left hemisphere-symmetric functional cortices.

Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data.

Functional connectivity in the auditory, visual, and sensorimotor cortices is characterized predominantly by frequencies slower than those in the cardiac and respiratory cycles, which are characterized by a high degree of temporal coherence.

Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: a meta-analysis