Widespread expressions of immunoglobulin superfamily proteins in cancer cells

  title={Widespread expressions of immunoglobulin superfamily proteins in cancer cells},
  author={Gregory W Lee and Mingang Zhu and Bixia Ge and Suzanne Potzold},
  journal={Cancer Immunology, Immunotherapy},
RP215 monoclonal antibody (Mab) was shown to recognize a carbohydrate-associated epitope of cancer cell–expressed glycoproteins, known as CA215. Extensive MALDI-TOF MS analysis was performed to search for the molecular identity of CA215. Besides immunoglobulin (Ig) heavy chains, homology to human T-cell receptors (TCR) and Ig-like cell adhesion molecules was also detected. By using RT-PCR and cDNA sequencing, it was observed that as many as 80% of cancer cell lines showed significant levels of… CONTINUE READING


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