Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells.

@article{Zhao1996WidespreadEO,
  title={Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells.},
  author={C Zhao and I F Wang and Robert I. Lehrer},
  journal={FEBS letters},
  year={1996},
  volume={396 2-3},
  pages={319-22}
}
We compared the expression of human alpha- and beta-defensins by various human tissues. mRNA for alpha-defensins HNP1-3, abundant in bone marrow, was detected in peripheral blood leukocytes, spleen and thymus by RT-PCR, which revealed alpha-defensins HD5 and HD6 only in the small intestine. In contrast, the pancreas and kidney expressed high levels of hBD-1 and lower levels of this beta-defensin were found in many organs by RT-PCR (salivary gland > trachea > prostate and placenta > thymus… CONTINUE READING
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