Widespread establishment and regulatory impact of Alu exons in human genes.

  title={Widespread establishment and regulatory impact of Alu exons in human genes.},
  author={Shihao Shen and Lan Lin and James J. Cai and Peng Jiang and Elizabeth J Kenkel and Mallory R Stroik and Seiko Sato and Beverly L. Davidson and Yi Xing},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 7},
The Alu element has been a major source of new exons during primate evolution. Thousands of human genes contain spliced exons derived from Alu elements. However, identifying Alu exons that have acquired genuine biological functions remains a major challenge. We investigated the creation and establishment of Alu exons in human genes, using transcriptome profiles of human tissues generated by high-throughput RNA sequencing (RNA-Seq) combined with extensive RT-PCR analysis. More than 25% of Alu… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 63 extracted citations


Publications referenced by this paper.
Showing 1-10 of 44 references

Similar Papers

Loading similar papers…