Widespread establishment and regulatory impact of Alu exons in human genes.

@article{Shen2011WidespreadEA,
  title={Widespread establishment and regulatory impact of Alu exons in human genes.},
  author={Shihao Shen and Lan Lin and James J. Cai and Peng Jiang and Elizabeth J Kenkel and Mallory R Stroik and Seiko Sato and Beverly L. Davidson and Yi Xing},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 7},
  pages={2837-42}
}
The Alu element has been a major source of new exons during primate evolution. Thousands of human genes contain spliced exons derived from Alu elements. However, identifying Alu exons that have acquired genuine biological functions remains a major challenge. We investigated the creation and establishment of Alu exons in human genes, using transcriptome profiles of human tissues generated by high-throughput RNA sequencing (RNA-Seq) combined with extensive RT-PCR analysis. More than 25% of Alu… CONTINUE READING
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