Widespread elimination of naturally occurring neuronal death in Bax-deficient mice.

@article{White1998WidespreadEO,
  title={Widespread elimination of naturally occurring neuronal death in Bax-deficient mice.},
  author={Fletcher A. White and Cynthia R. Keller-Peck and Charles M. Knudson and S Stanley J. Korsmeyer and William D. Snider},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 4},
  pages={1428-39}
}
The proapoptotic molecule BAX is required for death of sympathetic and motor neurons in the setting of trophic factor deprivation. Furthermore, adult Bax-/- mice have more motor neurons than do their wild-type counterparts. These findings raise the possibility that BAX regulates naturally occurring cell death during development in many neuronal populations. To test this idea, we assessed apoptosis using TUNEL labeling in several well-studied neural systems during embryonic and early postnatal… CONTINUE READING
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